The TVBL within Cancer Biology in the Division of Cancer & Stem Cells is a multi-disciplinary research laboratory working on biological basics of cancer and vascular biology, and how we can use this to translate new findings on mechanisms of cancer and vascular disease into novel therapeutic approaches for cancer and other diseases.



Research groups


The research in the TVBL currently includes five groups focussing on vascular biology, cancer genetics, pain mechanisms, hypoxia/acidosis, and microvascular imaging.


Group leaders

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 David Bates, Professor of Oncology

My research focusses on the biology of VEGF, regulation of angiogenesis, vascular permeability and control of splicing.

Kevin Gaston, Professor of Cancer Science

Abdol Shams Nateri, Associate Professor

Alan McIntyre, Assistant Professor

Kenton Arkill, Senior Research Fellow


The TVBL Resources.

Vacancies

We currently have no vacancies in the TVBL

PhD Studentships

 Click here to see opportunities. We also have self funded studentships available listed by PI.

Upcoming and recent Events

We have a dynamic and active training and social programme, including our defence of our DragonBoat race title.

Seminar Series

Recent Publications (2018)

N Beazley-Long, F Almahasneh, W Ashby, SM Bestall, MN Swift, A Durrant, CE Moss, AV Benest, RP Hulse, DO Bates, LF Donaldson. VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis Brain Behaviour and Immunity. 2018 Mar 14. pii: S0889-1591(18)30060-6

 SL Barratt, T Blythe, K Ourradi, C Jarrett, GI Welsh, DO Bates, AB Millar  Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF). Respir Res. 2018 Jan 15;19(1):9

M Stevens, CR Neal, AHJ Salmon, DO Bates, SJ Harper, S Oltean. VEGF-A165b restores normal glomerular water permeability in a diphtheria-toxin mouse model of glomerular injury. Nephron In Press

 DO Bates, N Beazley Long, AV Benest, X Ye, N Ved, RP Hulse, S Barratt, LF Donaldson, SJ Harper, M Peiris-Pages, DJ Tortonese, S Oltean, RR Foster Physiological role of vascular endothelial growth factors as homeostatic regulators. Comprehensive Physiology in press

2017

V Pang, DO Bates*, L Leach* Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A165a, VEGF-A165b, PLGF and VE-cadherin. Clinical Science 2017 Nov 23;131(23):2763-2775

 T Sae-lao, N Luplertlop , DO Bates, K Wongprasert. Sulfated galactans from the red seaweed Gracilaria fisheri inhibit migration of cholangiocarcinoma cells (CCA). J. Phytomedicine 2017 Dec 1;36:59-67

L Mortara, AV Benest, DO Bates, DM Noonan.. Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours? Current Opinions in Pharmacology Aug;35:66-74.

M Stevens, CR Neal, AHJ Salmon, DO Bates, S Oltean. The splice isoform VEGF165b protects against proteinuria in a transgenic mouse model with progressive depletion of all endogenous VEGF –A isoforms from the kidney. J Physiol 2017 Oct 1;595(19):6281-6298

KB Betteridge, KP Arkill, CR Neal, SJ Harper, RR Foster, SC Satchell, DO Bates AHJ Salmon. Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function. J Physiol 2017 Aug 1;595(15):5015-5035

M Pruszko, E Milano, M Forcato, S Donzelli, F Ganci, S DiAgostino, DO Bates, S Bicciato, M Zylicz, A, Zylicz, G Blandino, G Fontemaggi. The mutant p53-ID4 complex controls VEGFA isoforms production by recruiting lncRNA MALAT1. Embo Rep 2017 Aug;18(8):1331-1351

SL Barratt, T Blythe, C.Jarrett, K.Ourradi, G.Shelley- Fraser, M.Day, Y.Qui, SJ Harper, T Maher, S Oltean CJ Scotton, GI Welsh, DO Bates, AB Millar. Alveolar epithelial type II cell expression of VEGF-Axxxa is critical for development of Pulmonary Fibrosis: an anti-fibrotic role for VEGF-Axxxb anti-angiogenic isoforms? Am J Respir Crit Care Med. 2017 Aug 15;196(4): 479-493

T Sae-lao, R. Tohtong , DO Bates, K Wongprasert. A heparan sulfate mimic sulfated galactans up-regulated p-ERK and inhibited migration of cholangiocarcinoma cells (CCA). Am J Chinese Medicine. 2017;45(3):615-633.

N Ved, RP Hulse, SM Bestall, LF Donaldson, JW Bainbridge, DO Bates Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina. Clinical Science 2017 Jun 1;131(12):1225-1243

J Castle Miller, *DO Bates, *DJ Tortonese Angiogenesis dependent seasonal control of pituitary function Proc Nat Acad Sciences USA 2017 Mar 21;114(12):E2514-E2523

J Batson HD Toop, C Redondo, R Babaebi-Jadidi, A Chaikuad, SF Wearmouth, B Gibbons, C Allen, C Tallant, J Zhang, C Du, JC Hancox T Hawtrey, J Da Rocha, R Griffith, S Knapp, *DO Bates, *JC Morris Development of novel, potent SRPK1 inhibitors by kinase insert domain interactions. ACS Chem Biol 12(3):825-832

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Posters


Exonate Ltd is a spin out company of the TVBL, focussed on developing treatments for diseases involving altered splicing, particularly of VEGF.

Funding

Our funding comes from multiple sources. We gratefully acknowledge funding from the following bodies









Tumour and Vascular Biology Laboratories

Cancer Biology

Division of Cancer and Stem Cells

School of Medicine

The University of Nottingham
C Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 31135
email: cancer-biology@nottingham.ac.uk

Last edited, 17/6/2016.