We will shortly be recruiting additional staff directly
to the TVBL. Watch this space. Positions within Exonate
are also available.
Research scientist in in vivo pharmacology and visual science
Exonate Ltd, Nottingham.
is a fast growing, dynamic pharmaceutical company
focussing on translating discoveries in alternative
splicing technology to therapeutics. Exonate Ltd wish
to appoint a senior scientist in in vivo
pharmacology to its laboratories based at the
University of Nottingham to aid its drug development
program in vascular biology of the eye, to develop
treatments for age related macular degeneration and
This is a "hands-on"
scientific and technical role and the successful
candidate will be expected to remain active in the
laboratory and "lead from the bench." Reporting to
the Head of Biology, the candidate will have
responsibility for the design, planning, execution
and interpretation of in vivo studies
focused on identifying candidate molecules within
the area of ophthalmology. The candidate will drive
scientific excellence and lead by example in the lab
by demonstrating best practices in the development,
implementation and execution of in vivo
models. The post-holder will be expected to
communicate data to multidisciplinary teams. The
candidate must have strong written and oral
communication skills, be self-motivated, innovative,
a team player and must be able to work
Independently design, plan, execute and interpret complex in vivo studies focused on identifying small molecules within the area of ophthalmology
Formulation of small molecules for in vivo
Evaluation of endpoints from in vivo studies via techniques such as qPCR, IHC, ELISA, Mass Spectrometry and Western blots.
Plan, execute and interpret pharmacokinetic/pharmacodynamic studies.
Data presentation to multidisciplinary discovery teams.
Preparation of technical reports.
Identification of risks within function and development of contingencies plans to mitigate risk.
PhD in cell biology, pharmacology or relevant scientific discipline; minimum 3 years of work experience or relevant academic experience. MSc degree in a relevant scientific discipline with at least 6 years work experience.
Requirements & Education A broad understanding of cellular and molecular pharmacology concepts within the ophthalmology/angiogenesis field is essential. Previous experience in the biopharmaceutical industry is preferred with a successful record of project impact.
Experience with small animal imaging is highly desired
Experience in ophthalmology and animal models of disease and methodologies used to study ocular physiology.
In vivo skills include animal handling, dosing of small molecules, sample preparation, small animal surgery, imaging modalities and experience with more complex transgenic and knockout models.
Proficiency in laboratory bench skills such as ELISAs, Western blots, qPCR, Flow cytometry, and/or histology is required.
Experience in ex vivo ocular permeability assays is a plus
Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale
Detail oriented and able to problem solve and offer potential solutions
Excellent written and oral communication skills
Works independently or as part of a team in a fast-paced environment
Computer skills: Advanced knowledge of Excel, Word, Powerpoint and Graphpad prism
If you are interested and would like to be considered for the post, please apply with a covering letter and your CV outlining your suitability for this role.