We will shortly be recruiting additional staff directly to the TVBL. Watch this space. Positions within Exonate are also available.

Research scientist in in vivo pharmacology and visual science

Exonate Ltd, Nottingham.

Salary. £25000-£45000

Exonate Ltd  ( is a fast growing, dynamic pharmaceutical company focussing on translating discoveries in alternative splicing technology to therapeutics. Exonate Ltd wish to appoint a senior scientist in in vivo pharmacology to its laboratories based at the University of Nottingham to aid its drug development program in vascular biology of the eye, to develop treatments for age related macular degeneration and diabetic retinopathy. 

This is a "hands-on" scientific and technical role and the successful candidate will be expected to remain active in the laboratory and "lead from the bench." Reporting to the Head of Biology, the candidate will have responsibility for the design, planning, execution and interpretation of in vivo studies focused on identifying candidate molecules within the area of ophthalmology. The candidate will drive scientific excellence and lead by example in the lab by demonstrating best practices in the development, implementation and execution of in vivo models. The post-holder will be expected to communicate data to multidisciplinary teams. The candidate must have strong written and oral communication skills, be self-motivated, innovative, a team player and must be able to work independently.


    Independently design, plan, execute and interpret complex in vivo studies focused on identifying small molecules within the area of ophthalmology
    Formulation of small molecules for in vivo
    Evaluation of endpoints from in vivo studies via techniques such as qPCR, IHC, ELISA, Mass Spectrometry and Western blots.
    Plan, execute and interpret pharmacokinetic/pharmacodynamic studies.
    Data presentation to multidisciplinary discovery teams.
    Preparation of technical reports.
    Identification of risks within function and development of contingencies plans to mitigate risk.



PhD in cell biology, pharmacology or relevant scientific discipline; minimum 3 years of work experience or relevant academic experience. MSc degree in a relevant scientific discipline with at least 6 years work experience.

Requirements & Education A broad understanding of cellular and molecular pharmacology concepts within the ophthalmology/angiogenesis field is essential. Previous experience in the biopharmaceutical industry is preferred with a successful record of project impact.

Technical Skills

Experience with small animal imaging is highly desired
Experience in ophthalmology and animal models of disease and methodologies used to study ocular physiology.
In vivo skills include animal handling, dosing of small molecules, sample preparation, small animal surgery, imaging modalities and experience with more complex transgenic and knockout models.
Proficiency in laboratory bench skills such as ELISAs, Western blots, qPCR, Flow cytometry, and/or histology is required.
Experience in ex vivo ocular permeability assays is a plus
Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale
Detail oriented and able to problem solve and offer potential solutions
Excellent written and oral communication skills
Works independently or as part of a team in a fast-paced environment
Computer skills: Advanced knowledge of Excel, Word, Powerpoint and Graphpad prism

If you are interested and would like to be considered for the post, please apply with a covering letter and your CV outlining your suitability for this role.


Applicants should contact, to discuss the position informally, or submit a CV directly to



Tumour and Vascular Biology Laboratories

Cancer Biology

Division of Cancer and Stem Cells

School of Medicine

The University of Nottingham
C Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0) 115 82 31135

Last edited, 17/6/2016.