Vacancies


Postdoc in Vascular Biology

We are seeking a self-motivated, dynamic and dedicated postdoctoral research assistant to join the new Benest lab.  The project will aim to unravel transcriptional control of endothelial quiescence during development, and pathological conditions.  The project is funded by the British Heart foundation.  You will be  a member of a new and dynamic research group, working closely with a new PI within the TVBL.  Opportunity to co-supervise undergraduate and Masters students, and attend international conferences will be provided.

The ideal candidate will have, or be close to obtaining their PhD, preferably with a working knowledge of endothelial cells.  Full training in several animal models will be given, but an appreciation of how complex in vivo systems can be studied at a transcriptomic, and cellular level would be advantageous.

The is a fulltime 2 year post. To express an interest in this post email: Andrew.Benest@nottingham.ac.uk

Postdoc in Translational Cardiovascular Research

The Tumour and Vascular Biology Laboratories (www.tvbl-nottingham.org) in the School of Medicine seeks to appoint a postdoctoral research fellow to investigate the potential for a new treatment for peripheral ischemic disease.  This BHF funded position in Prof Bates' lab will focus on determining whether a new treatment for arterial disease can be generated using a monoclonal antibody to anti-angiogenic VEGF isoforms. You will be expected to have a PhD in Physiology, Cell Biology, Biochemistry or relevant subject and an emphasis on cardiovascular biology, preferably with experience of in vivo models of ischemia, immunoprecipitation, cell biology assays and biochemical assays. You will work within a large and exciting team focussing on diverse problems from trying to find treatments for cardiovascular disease, cancer and blindness to understanding basic mechanisms of cell biology.

The Project
The development of new vessels in health and disease is dominated by vascular endothelial growth factor-A (VEGF). One family of VEGF splice forms is pro-angiogenic, pro-permeability and vasodilatory (e.g. VEGF165). We were the first to identify a sister family of isoforms that have opposing properties (e.g. VEGF165b) and are expressed in normal human tissues, and upregulated in patients with arterial disease. In numerous in vivo angiogenesis models the angiogenic phenotype of VEGF has been shown to depend on the balance of its isoform families, such that control of VEGF165b is now in clinical development as a therapeutic in human angiogenic eye disease.  To identify the angiogenic potential of regulating VEGF isoform availability in patients with arterial disease, we have developed antibodies with therapeutic potential. We are optimising these antibodies, and  will test whether they can stimulate re-growth of blood vessels in cellular and animal models of disease. This study could lay the basis for a new class of therapeutic strategies for vascular disease. 

To express an interest in this post email: David.Bates@nottingham.ac.uk

Postdoc in Neuroendocrinology and Angiogenesis

Project title: Angiogenic mechanisms underlying seasonal adaptation to a changing environment.
Duration: 36 months. Salary: Grade J, £36,613 / £41212 per year.
Funding body: BBSRC
We are seeking a flexible postdoc prepared to work based in Bristol, but also spending up to a year in the TVBL in Nottingham. This three way collaboration between the Universities of Bristol, Nottingham and Aberdeen will investigate the role of angiogenesis in neuroendocrine control of seasonal adaptation in horses, sheep and hamsters. Candidates must hold a PhD or equivalent in Neuroendocrinology, Chronobiology, Angiogenesis, or Physiology. The successful candidate must possess outstanding experimental and laboratory skills relevant to this role, as well as demonstrable success in in vivo work, tissue culture and data management. Practical experience in the use of research methodologies and techniques in molecular biology are essential for this post.

We have recently shown that a mechanism regulating angiogenesis within the pituitary gland participates in the seasonal adjustment of photoperiodic species to a changing environment by: a) controlling the remodelling of the pituitary microvasculature; and b) acting as messenger signals from the melatonin sensitive pars tuberalis (PT) to the endocrine cells of the pars distalis involved in the regulation of seasonal fertility. Here we will investigate whether this is a conserved system of adaptation, operating in species that reproduce at different times of the year, and examine the intra- and inter-cellular pathways underlying this process. It is well established that the pattern of melatonin secretion from the pineal gland decodes day length information through a direct action in the PT. The overall hypothesis of this project is that differential expression of VEGF-A isoforms within the pituitary participate in the melatonin signal readout to translate photoperiodic cues into an annual physiological response. We will investigate melatonin-induced VEGF-A alternative splicing and assess the implication of clock genes in the VEGF-A regulation of seasonal physiology using whole animal systems and in vitro strategies.

To express an interest in this post email: David.Bates@nottingham.ac.uk



Tumour and Vascular Biology Laboratories

Cancer Biology

Division of Cancer and Stem Cells

School of Medicine

The University of Nottingham
C Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 31135
email: cancer-biology@nottingham.ac.uk

Last edited, 17/6/2016.